That momentous dichotomy exists because if there were transformations that technology could never achieve regardless of what knowledge was brought to bear, then this fact would itself be a testable regularity in nature. But all regularities in nature have explanations, so the explanation of that regularity would itself be a law of nature, or a consequence of one. And so, again, everything that is not forbidden by laws of nature is achievable, given the right knowledge.
my "aha" moments and much more!!